Here is a Powerpoint presentation by AstraZenecas' modestly titled Head of Global Development, Martin Nicklasson.
The first few slides hit the nail on the head regarding the "blockbuster" problems facing Big Pharma.
Shame it then loses its way a bit when it comes to solutions.
http://www.mond.org/SCI/SCIpharm2004/Plenary-M_Nicklasson.pdf
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