A new US Senate Finance Committee report has alleged that Glaxo tried to silence Dr. John Buse, a diabetes expert and professor of medicine at the University of North Carolina in Chapel Hill. In 1999, Dr. Buse began expressing concerns about the cardiovascular risks of Avandia.
Earlier this summer, the Senate committee heard testimony from Dr. Buse, who said he felt pressured by the drug’s maker, SmithKlineBeecham (now part of GlaxoSmithKline) to sign a clarifying statement drafted by the company that downplayed his concerns. During his testimony, Dr. Buse described name-calling and what he said was the veiled threat of a lawsuit by a high-ranking drug company executive after he had criticized Avandia at a medical meeting. Dr. Buse also testified that Glaxo complained about him to his supervisors at the University of North Carolina.
Now, the Senate Committee has implicated two high-ranking Glaxo executives in the intimidation campaign against Dr. Buse. The report alleges that Glaxo Chief Executive Jean-Pierre Garnier and former research chief Tachi Yamada were involved in the intimidation.
Dr. Buse had also named Yamada in testimony to the Senate committee.
For its part, Glaxo told the Wall Street Journal that it denies trying to stifle Dr. Buse. A spokesperson told the newspaper that it disputes the committee’s conclusions. However, the spokesperson conceded that Glaxo had tried to correct Dr. Buse’s “inaccuracies”
“People at the time were very passionate about this new medicine and could perhaps have handled the interactions with Dr. Buse better,” the Glaxo spokesperson said. “We did apologize to Dr. Buse for the tone of some of the conversations.”
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