All along, a handful of researchers have predicted that amyloid-blocking drugs could actually make the disease worse. One critic is Mark Smith at Case-Western-Reserve University in Cleveland. He is on vacation abroad now, but here is what he said in 2008:
Others say the Alzheimer’s field has it backwards. Far from being harmful, amyloid is “actually a response to injury that the brain secretes to protect itself, like a scar,” argues Mark Smith, a neuroscientist at Case Western Reserve University. By removing it, “you will make the disease worse.” Amyloid deposits are often found near cerebral blood vessels, hinting that amyloid may act as a sealant for damaged blood vessels.
via blogs.forbes.com
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