via guardian.co.uk
The medicine that typically gives an extra six weeks of life is too expensive for NHS, watchdog rules. Avastin costs almost £21,000 per patient and an estimated 6,500 people in the UK could have been eligible to try the drug.
However, patients may still be able to access the drug through the government's new cancer drugs fund. Some £50m is currently in the fund, and an extra £200m will be available from April.
Regional panels of doctors and cancer specialists are in charge of deciding which patients should benefit from the cash.
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The problem with Avastin is the same thing that was a problem with AZT for HIV/AIDS. Early results, then rapid resistance. The solution is "combination therapy" to attack all the different targets.
Tumor vasculature needs VEGF to survive. Avastin removes VEGF, killing blood vessels. But other pro-angiogenic factors can substitute for VEGF: FGF, PDGF, ephrin A1, angioprotein 1, IL-8 etc.
We need to attack these other targets as well. If you can achieve this, then you really don't need the other drugs, which really don't get into the tumor so well. But angiogenic attack provides true selective toxicity, something which is sorely lacking with all of the other treatments.
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