Thursday, May 02, 2013

Suspect surrogate end points

  • Clofibrate reduced cholesterol in persons at risk for heart disease.  Lower cholesterol is associated with a lower risk for heart disease.  Unfortunately, patients who took clofibrate were more likely to die.
  • Encainide reduces the number premature heart beats (PVCs) is persons who have had heart attacks.  PVCs are strongly associated with a higher risk of death after a heart attack.  Unfortunately, patients who took encainide after heart attacks were much more likely to die.  It is estimated that encainide caused thousands of excess deaths.
  • Rosiglatazone lowers the glycohemoglobin level in persons with diabetes.  Diabetes is a risk factor for heart disease and lower glycohemoglobin levels indicate better diabetes control. Unfortunately, patients who took rosiglitazone had more heart attacks.

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