The study was funded by the US National Institute of Mental Health and US Agency for Healthcare Research and Quality. Gibbons and his colleagues from the University of Miami and Columbia University also used data from a National Institute of Health collaborative study of fluoxetine and venlafaxine.Relative to placebo, fluoxetine seemed to have no effect either way on suicidal thoughts and behaviour in children but it did lead to a lowering in the severity of depressive symptoms. In adult and geriatric patients taking antidepressants, there was a significant reduction in depression and suicide risk over time compared with patients taking placebo.Gibbons said the differences between his study and that of the FDA might be partly explained by the fact that if a patient overdosed with one of the drugs under study and ended up in the emergency room, this event would be recorded. But if a patient tried to overdose on a placebo, it would be up to that patient to reveal the event.
via thelancet.com
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