"Futile" anti-depressants

Prescribing anti-depressants to the vast majority of patients is futile, as the drugs have little or no impact at all, according to researchers.

Almost 50 clinical trials were reviewed by psychologists from the University of Hull who found that new-generation anti-depressants worked no better than a placebo - a dummy pill - for mildly depressed patients.

Even the trials that suggested some clinical benefit for the most severely depressed patients did not produce convincing evidence. Professor Irving Kirsch from the university's pyschology department said: "The difference in improvement between patients taking placebos and patients taking anti-depressants is not very great.

"This means that depressed people can improve without chemical treatments. Given these results, there seems little reason to prescribe anti-depressant medication to any but the most severely depressed patients."

The researchers focused on four widely prescribed anti-depressants and the clinical trials that were submitted to win licensing approval from the US Food and Drug Administration.

The drugs included fluoxetine (Prozac), venlafaxine (Efexor), and paroxetine (Seroxat/Paxil).

More at FT